PRME

Prime Medicine Inc.

DOUBTFUL — SCREEN DOES NOT PASSstock

Is PRME Halal?

Prime editing technology — bioethics consultation needed.

What You Should Know

Next-gen CRISPR with fewer errors. Its March 31, 2026 Form 10-Q reports $294.730 million of assets, $114.512 million of operating-lease liabilities, $64.106 million of cash, $71.391 million of debt securities and $0.856 million of quarterly collaboration revenue. Debt/assets is 38.85%, liquidity/assets is 45.97% and disclosed interest income is 119.28% of revenue; the examined financial screens fail. Same ethical considerations as other gene-editing firms. Consult scholar.

⚠️ Concerns

  • Gene editing ethics
  • Debt, liquidity and income screens fail

Current quantitative Sharia screen

Based on 10-Q figures for the period ended 2026-03-31; calculated 2026-07-15.

USD · millions
Interest-bearing debt / assets
38.85%Above limit
Below 33.333% under FTSE Yasaar

114.512 / 294.73

Cash + interest-bearing securities / assets
45.97%Above limit
Below 33.333% under FTSE Yasaar

135.497 / 294.73

Receivables + cash / assets
21.75%Within limit
Below 50% under FTSE Yasaar

64.106 / 294.73

Non-compliant income / revenue
119.28%Above limit
No more than 5% under FTSE Yasaar

1.021 / 0.856

FTSE Yasaar
v4.6, February 2026
Financial
Fails
Overall
Fails

Debt/assets is 38.85%, liquidity/assets is 45.97% and disclosed interest income is 119.28% of revenue; the examined financial limits fail.

MSCI Islamic (total-assets series)
October 2024 methodology
Financial
Fails
Overall
Fails

Debt/assets is 38.85% and liquidity/assets is 45.97%, above the examined MSCI total-assets limits; receivables-plus-cash/assets is 21.75%.

Malaysia SAC financial ratios
single 5% activity benchmark adopted November 2025
Financial
Fails
Overall
Fails

Debt/assets is 38.85% and liquidity/assets is 45.97%, above the examined Malaysia 33% limits. This calculation is not an official classification.

Market-cap denominator methods
MSCI M-Series, S&P and Dow Jones methods differ
Financial
Not calculated
Overall
Incomplete

A properly licensed and reproducible historical market-cap series is not stored; filing-based asset ratios remain documented.

Business-activity disclosure

Prime Medicine develops prime-editing therapies for genetic disease. Therapeutic healthcare is generally permissible, while gene-editing boundaries, licensing and program allocation require qualified scholarly review.

Limitation: The filing does not provide a universal prohibited-activity numerator across collaborations and therapeutic programs.

Purification

Prime Medicine discloses $1.021 million of interest income, but no scholar-approved purification percentage is asserted for the operating business.

Inputs, assumptions and primary sources
  • Amounts are USD millions from Prime Medicine's March 31, 2026 Form 10-Q.
  • Conservative debt is the $114.512 million current and noncurrent operating-lease liability; no separate borrowing balance is tagged in the filing facts.
  • Cash and cash equivalents are $64.106 million and current available-for-sale debt securities are $71.391 million; no separate accounts-receivable balance is tagged.
  • Quarterly collaboration revenue is $0.856 million and disclosed interest income is $1.021 million, or 119.28% of revenue.
  • Prime editing therapeutics are generally permissible in the retained qualitative analysis, but gene-editing boundaries and clinical-program allocation remain case-dependent.

This is a reproducible financial screen, not a fatwa. A failed total-assets screen can coexist with a pass under a market-cap methodology. ZakatInvest keeps the qualitative assessment separate so numerical thresholds do not erase material context.

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